Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.
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Joyce M
Ngoi
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Jones
Gyamfi
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Dominic SY
Amuzu
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Benjamin D
Nuertey
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Philip M
Soglo
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Vincent
Appiah
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Ivy A
Asante
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Paul
Owusu-Oduro
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Samuel
Armoo
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Dennis
Adu-Gyasi
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Nicholas
Amoako
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Joseph
Oliver-Commey
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Michael
Owusu
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Augustina
Sylverken
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Edward D
Fenteng
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Violette V
M'cormack
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Frederick
Tei-Maya
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Evelyn B
Quansah
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Reuben
Ayivor-Djanie
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Enock K
Amoako
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Isaac T
Ogbe
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Bright K
Yemi
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Israel
Osei-Wusu
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Deborah NA
Mettle
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Samirah
Saiid
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Kesego
Tapela
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Francis
Dzabeng
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Vanessa
Magnussen
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Jerry
Quaye
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Precious C
Opurum
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Rosina A
Carr
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Patrick T
Ababio
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Abdul-Karim
Abass
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Samuel K
Akoriyea
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Emmanuella
Amoako
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Frederick
Kumi-Ansah
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Oliver D
Boakye
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Dam K
Mibut
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Theophilus
Odoom
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Lawrence
Ofori-Boadu
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Emmanuel
Allegye-Cudjoe
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Sylvester
Dassah
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Victor
Asoala
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Kwaku P
Asante
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Richard O
Phillips
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Mike Y
Osei-Atweneboana
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John O
Gyapong
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Patrick
Kuma-Aboagye
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William K
Ampofo
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Kwabena O
Duedu
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Nicaise T
Ndam
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Yaw
Bediako
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Peter K
Quashie
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Lucas N
Amenga-Etego
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Gordon A
Awandare
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(2022)
Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.
Nature Communications, 13 (1).
p. 2494.
ISSN 2041-1723
DOI: 10.1038/s41467-022-30219-5
The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
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