Epidemiology and genetic analysis of praziquantel treatment response of Schistosoma mansoni in preschool-aged children in Uganda

This thesis investigates the treatment responses to praziquantel in preschool-aged children with intestinal schistosomiasis in Uganda. The first data chapter examines the efficacy of praziquantel in clearing Schistosoma mansoni infections amongst preschool-aged children enrolled in a clinical trial, assessing post-treatment parasitological outcomes and identifying factors influencing treatment success. The second chapter focuses on characterising the population structure of Schistosoma mansoni in Uganda, exploring how the genetic diversity of parasite populations is distributed across geographical regions and over time. This analysis provides insights into the movement and persistence of parasite populations, which may have implications for regional control efforts. The final chapter delves into the genetic basis for sub-optimal praziquantel efficacy, investigating potential genomic markers which may be associated with reduced worm clearance. Together these chapters aim to provide a comprehensive understanding of praziquantel treatment responses and contribute to more effective schistosomiasis control strategies in young children.