Segmenting the Global Layers of Malignant Meningioma: A Population-Based Study of Incidence, Risk Factors, and Temporal Trends.

BACKGROUND: Malignant meningioma is a rare form of primary central nervous system cancer originating from the meninges membrane layers. Current data remain unmapped to cover trends for particular groups globally. METHODS: This study examined the missing gap for its global burden, country-specific incidence, and risk factor trends, stratified by sex and age. Several databases were retrieved for temporal trend analysis and interpretation: Cancer incidence rates from five continents (CI5 Plus), global cancer observatory (GLOBOCAN), global burden of disease (GBD), and the world bank. association between malignant meningioma's and various factors was determined using linear regression. Meningioma incidence trends were estimated using the average annual percentage change (AAPC) with join point regression, including the shift in cancerous meningioma incidence based on corresponding specific variables. RESULT: New malignant meningioma cases reported in 2020 were estimated to be 14,832 with aged-standardized rates (ASR) of 1.3 per million population. Considerable variations exist among nations for malignant meningioma's, with the highest ASR found in Latvia (6.9 per million population), compared to a 345-fold difference from the lowest ASR found in Fiji (0.02 per million population). Additionally, chronic disease presence such as smoking and hypertension was associated with higher malignant meningioma incidence. The analysis observed increasing rates of malignant meningioma in younger populations. CONCLUSIONS: Overall, this study contributes a global perspective on malignant meningioma incidence and emphasizes further investigation of specific groups that may have been overlooked. The increasing trend of malignant meningioma in younger populations warrants preventive, early diagnosis, and further research initiatives for evidence on risk management.