IMC1g knockdowns reveal malaria blood-stage alveolin functions.

Annie Z Tremp ORCID logo ; Sadia Saeed ; Johannes T Dessens ORCID logo ; (2024) IMC1g knockdowns reveal malaria blood-stage alveolin functions. Trends in parasitology, 41 (1). pp. 16-18. ISSN 1471-4922 DOI: 10.1016/j.pt.2024.11.012
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Plasmodium alveolins are cytoskeletal proteins with important roles in cell shape, tensile strength, and motility of mosquito-stage ookinetes and sporozoites. Two recent studies by Cepeda Diaz et al. and Liu et al. employ inducible knockdown of the essential blood-stage-expressed alveolin IMC1g to identify new roles in merozoite intracellular survival, schizogonic cell division, and male gametogenesis.


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