World Tuberculosis (TB) Day, March 24th, 2023, will commemorate the day in 1882 when Professor Robert Koch announced his discovery of Mycobacterium tuberculosis (Mtb) when TB ravaged Europe. Over a century later, in 1993, the World Health Organization (WHO) declared TB a global health emergency. Since then, there have been 60 million deaths due to TB. The tragic state of affairs reflects a great paradox – that, despite affordable and effective TB treatment being available for the past seven decades, the latest 2022 WHO Annual Global Tuberculosis Report highlights that TB remains a leading cause of ill health and death from an infectious disease worldwide [1]. In 2021, the WHO estimated that 10.6 million people fell sick with TB worldwide: six million men, 3.4 million women and 1.2 million children. Multidrug-resistant TB (MDR-TB) remains a threat to global health security. Only one in three people with drug-resistant TB can access treatment; many remain undiagnosed and untreated. TB today occurs in every part of the world. An estimated 1 billion people have latent Mtb infection (LTBI), where the mycobacteria do not cause clinical disease but serve as a reservoir and can re-activate at any time under conditions of stress, malnutrition, poor housing, co-infections and co-morbidities, among other [35]