Strong evidence suggests that HIV self-testing is highly acceptable to cisgender gay, bisexual and other men who have sex with men (GBMSM), trans and gender diverse people in England and Wales, and that this novel technology can make a meaningful difference to HIV testing behaviours. HIV self-testing is feasible to deliver at large scale, can increase testing uptake and frequency without negatively impacting on linkage to care or testing for sexually transmitted infections (STIs). Question remain as to how best to deliver HIV self-testing in a way that responds to entrenched health inequalities. This Implementation action framework and tool-kit has been produced to facilitate and promote HIV self-testing service delivery in England and Wales with the key goal of improving health equity.