Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China.

Shen Tian ; Xingyong Wu ; Lin Liu ; Anyang Li ; Xuemiao Li ; Hua Pei ; Yanshuang Wang ; David AB Dance ORCID logo ; Hai Chen ; Qianfeng Xia ; (2024) Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China. Drug resistance updates, 76. 101121-. ISSN 1368-7646 DOI: 10.1016/j.drup.2024.101121
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In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.

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