DNA methylation in peripheral tissues and left-handedness.

Veronika V Odintsova ; Matthew Suderman ; Fiona A Hagenbeek ; Doretta Caramaschi ; Jouke-Jan Hottenga ; René Pool ; BIOS Consortium ; Conor V Dolan ; Lannie Ligthart ; Catharina EM van Beijsterveldt ; +10 more... Gonneke Willemsen ; Eco JC de Geus ; Jeffrey J Beck ; Erik A Ehli ; Gabriel Cuellar-Partida ; David M Evans ; Sarah E Medland ; Caroline L Relton ORCID logo ; Dorret I Boomsma ; Jenny van Dongen ; (2022) DNA methylation in peripheral tissues and left-handedness. Scientific reports, 12 (1). 5606-. ISSN 2045-2322 DOI: 10.1038/s41598-022-08998-0
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Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355-0.578]), but inconsistent across tissues (correlation range [- 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.


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