DNA methylation in peripheral tissues and left-handedness.

Odintsova, VV; Suderman, M; Hagenbeek, FA; Caramaschi, D; Hottenga, J; Pool, R; BIOS Consortium; Dolan, CV; Ligthart, L; van Beijsterveldt, CE; +10 more...Willemsen, G; de Geus, EJ; Beck, JJ; Ehli, EA; Cuellar-Partida, G; Evans, DM; Medland, SE; Relton, CLORCID logo; Boomsma, DI; van Dongen, J and (2022) DNA methylation in peripheral tissues and left-handedness. Scientific reports, 12 (1). 5606-. ISSN 2045-2322 DOI: 10.1038/s41598-022-08998-0
Copy

Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355-0.578]), but inconsistent across tissues (correlation range [- 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.


picture_as_pdf
Odintsova-etal-2022-DNA-methylation-in-peripheral-tissues-and-left-handedness.pdf
subject
Published Version
Available under Creative Commons: Attribution 4.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads