Vekemans, Johan; Schellenberg, David; Benns, Sarah; O'Brien, Kate; Alonso, Pedro; (2021) Meeting report: WHO consultation on malaria vaccine development, Geneva, 15-16 July 2019. Vaccine, 39 (22). pp. 2907-2916. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2021.03.093
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
Considerable progress has been made in malaria control in the last two decades, but progress has stalled in the last few years. New tools are needed to achieve public health goals in malaria control and elimination. A first generation vaccine, RTS,S/AS01, is currently being evaluated as it undergoes pilot implementation through routine health systems in parts of three African countries. The development of this vaccine took over 30 years and has been full of uncertainties. Even now, important unknowns remain as to its future role in public health. Lessons need to be learnt for second generation and future vaccines, including how to facilitate early planning of investments, streamlining of development, regulatory and policy pathways. A number of candidate vaccines populate the current development pipeline, some of which have the potential to contribute to burden reduction if efficacy is confirmed in conditions of natural exposure, and if they are amenable to affordable supply and programmatic implementation. New, innovative technologies will be needed if future malaria vaccines are to overcome important scientific hurdles and induce durable, high level protection. WHO convened a stakeholder consultation on the status of malaria vaccine research and development to inform the recently reconstituted Malaria Vaccine Advisory Committee (MALVAC) which will assist WHO in updating its current guidance and recommendations about priorities and product preferences for malaria vaccines.
Item Type | Article |
---|---|
Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Research Centre | Vaccine Centre |
PubMed ID | 33931251 |
Elements ID | 163203 |
Official URL | http://dx.doi.org/10.1016/j.vaccine.2021.03.093 |
Download
Filename: Vekemans-etal-2021-WHO-consultation-on-malaria-vaccine.pdf
Description: This is an author accepted manuscript version of an article accepted for publication, and following peer review. Please be aware that minor differences may exist between this version and the final version if you wish to cite from it.
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Download