Estimating an EQ-5D-3L Value Set for Romania Using Time Trade-Off.
Paveliu, Marian Sorin;
Olariu, Elena;
Caplescu, Raluca;
Oluboyede, Yemi;
Niculescu-Aron, Ileana-Gabriela;
Ernu, Simona;
Vale, Luke;
(2021)
Estimating an EQ-5D-3L Value Set for Romania Using Time Trade-Off.
International journal of environmental research and public health, 18 (14).
p. 7415.
ISSN 1661-7827
DOI: https://doi.org/10.3390/ijerph18147415
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OBJECTIVE: To provide health-related quality of life (HRQoL) data to support health technology assessment (HTA) and reimbursement decisions in Romania, by developing a country-specific value set for the EQ-5D-3L questionnaire. METHODS: We used the cTTO method to elicit health state values using a computer-assisted personal interviewing approach. Interviews were standardized following the most recent version of the EQ-VT protocol developed by the EuroQoL Foundation. Thirty EQ-5D-3L health states were randomly assigned to respondents in blocks of three. Econometric modeling was used to estimate values for all 243 states described by the EQ-5D-3L. RESULTS: Data from 1556 non-institutionalized adults aged 18 years and older, selected from a national representative sample, were used to build the value set. All tested models were logically consistent; the final model chosen to generate the value set was an interval regression model. The predicted EQ-5D-3L values ranged from 0.969 to 0.399, and the relative importance of EQ-5D-3L dimensions was in the following order: mobility, pain/discomfort, self-care, anxiety/depression, and usual activities. CONCLUSIONS: These results can support reimbursement decisions and allow regional cross-country comparisons between health technologies. This study lays a stepping stone in the development of a health technology assessment process more driven by locally relevant data in Romania.