This document introduces the processes involved in setting up the IT infrastructure on the cloud for hosting the data hub of INSPIRE EA network. The main objective here is to outline the approaches, methods, and implementation tasks that were undertaken to set up this infrastructure to facilitate data storage, data processing, and data accessibility features for the network. This setup allowed the storage of input datasets in various formats along with applications for extracting, transforming, and loading pipelines to populate the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). It also provided access to tools for data mapping, data documentation, and data analysis for respective roles within the collaborating and network partner institutions.