Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites.

Aline Fréville ORCID logo ; Margarida Ressurreição ; Christiaan van Ooij ORCID logo ; (2023) Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites. mBio, 15 (1). e0122323-. DOI: 10.1128/mbio.01223-23
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In the manuscript, the authors investigate the role of the protease Plasmepsin V in the parasite-host interaction. Whereas processing by Plasmepsin V was previously thought to target a protein for export into the host cell, the authors now show that there are proteins cleaved by this protease that are not exported but instead function at the host-parasite interface. This changes the view of this protease, which turns out to have a much broader role than anticipated. The result shows that the protease may have a function much more similar to that of related organisms. The authors also investigate the requirements for protein export by analyzing exported and non-exported proteins and find commonalities between the proteins of each set that further our understanding of the requirements for protein export.


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