Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites.
In the manuscript, the authors investigate the role of the protease Plasmepsin V in the parasite-host interaction. Whereas processing by Plasmepsin V was previously thought to target a protein for export into the host cell, the authors now show that there are proteins cleaved by this protease that are not exported but instead function at the host-parasite interface. This changes the view of this protease, which turns out to have a much broader role than anticipated. The result shows that the protease may have a function much more similar to that of related organisms. The authors also investigate the requirements for protein export by analyzing exported and non-exported proteins and find commonalities between the proteins of each set that further our understanding of the requirements for protein export.
Item Type | Article |
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Elements ID | 212665 |
Official URL | http://dx.doi.org/10.1128/mbio.01223-23 |
Date Deposited | 15 Dec 2023 16:50 |