Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Wang, A
; Shen, J; Rodriguez, AA; Saunders, EJ; Chen, F; Janivara, R; Darst, BF; Sheng, X; Xu, Y; Chou, AJ; +282 more...Benlloch, S; Dadaev, T; Brook, MN; Plym, A; Sahimi, A; Hoffman, TJ; Takahashi, A; Matsuda, K; Momozawa, Y; Fujita, M; Laisk, T; Figuerêdo, J; Muir, K; Ito, S; Liu, X; Biobank Japan Project; Uchio, Y; Kubo, M; Kamatani, Y; Lophatananon, A; Wan, P; Andrews, C; Lori, A; Choudhury, PP; Schleutker, J; Tammela, TL; Sipeky, C; Auvinen, A; Giles, GG; Southey, MC; MacInnis, RJ; Cybulski, C; Wokolorczyk, D; Lubinski, J; Rentsch, CT; Cho, K; Mcmahon, BH; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bojesen, SE; Røder, A; Stroomberg, HV; Batra, J; Chambers, S; Horvath, L; Clements, JA; Tilly, W; Risbridger, GP; Gronberg, H; Aly, M; Szulkin, R; Eklund, M; Nordstrom, T; Pashayan, N; Dunning, AM; Ghoussaini, M; Travis, RC; Key, TJ; Riboli, E; Park, JY; Sellers, TA; Lin, H; Albanes, D; Weinstein, S; Cook, MB; Mucci, LA; Giovannucci, E; Lindstrom, S; Kraft, P; Hunter, DJ; Penney, KL; Turman, C; Tangen, CM; Goodman, PJ; Thompson, IM; Hamilton, RJ; Fleshner, NE; Finelli, A; Parent, M; Stanford, JL; Ostrander, EA; Koutros, S; Beane Freeman, LE; Stampfer, M; Wolk, A; Håkansson, N; Andriole, GL; Hoover, RN; Machiela, MJ; Sørensen, KD; Borre, M; Blot, WJ; Zheng, W; Yeboah, ED; Mensah, JE; Lu, Y; Zhang, H; Feng, N; Mao, X; Wu, Y; Zhao, S; Sun, Z; Thibodeau, SN; McDonnell, SK; Schaid, DJ; West, CM; Barnett, G; Maier, C; Schnoeller, T; Luedeke, M; Kibel, AS; Drake, BF; Cussenot, O; Cancel-Tassin, G; Menegaux, F; Truong, T; Koudou, YA; John, EM; Grindedal, EM; Maehle, L; Khaw, K; Ingles, SA; Stern, MC; Vega, A; Gómez-Caamaño, A; Fachal, L; Rosenstein, BS; Kerns, SL; Ostrer, H; Teixeira, MR; Paulo, P; Brandão, A; Watya, S; Lubwama, A; Bensen, JT; Butler, EN; Mohler, JL; Taylor, JA; Kogevinas, M; Dierssen-Sotos, T; Castaño-Vinyals, G; Cannon-Albright, L; Teerlink, CC; Huff, CD; Pilie, P; Yu, Y; Bohlender, RJ; Gu, J; Strom, SS; Multigner, L; Blanchet, P; Brureau, L; Kaneva, R; Slavov, C; Mitev, V; Leach, RJ; Brenner, H; Chen, X; Holleczek, B; Schöttker, B; Klein, EA; Hsing, AW; Kittles, RA; Murphy, AB; Logothetis, CJ; Kim, J; Neuhausen, SL; Steele, L; Ding, YC; Isaacs, WB; Nemesure, B; Hennis, AJ; Carpten, J; Pandha, H; Michael, A; De Ruyck, K; De Meerleer, G; Ost, P; Xu, J; Razack, A; Lim, J; Teo, S; Newcomb, LF; Lin, DW; Fowke, JH; Neslund-Dudas, CM; Rybicki, BA; Gamulin, M; Lessel, D; Kulis, T; Usmani, N; Abraham, A; Singhal, S; Parliament, M; Claessens, F; Joniau, S; Van den Broeck, T; Gago-Dominguez, M; Castelao, JE; Martinez, ME; Larkin, S; Townsend, PA; Aukim-Hastie, C; Bush, WS; Aldrich, MC; Crawford, DC; Srivastava, S; Cullen, J; Petrovics, G; Casey, G; Wang, Y; Tettey, Y; Lachance, J; Tang, W; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Yamoah, K; Govindasami, K; Chokkalingam, AP; Keaton, JM; Hellwege, JN; Clark, PE; Jalloh, M; Gueye, SM; Niang, L; Ogunbiyi, O; Shittu, O; Amodu, O; Adebiyi, AO; Aisuodionoe-Shadrach, OI; Ajibola, HO; Jamda, MA; Oluwole, OP; Nwegbu, M; Adusei, B; Mante, S; Darkwa-Abrahams, A; Diop, H; Gundell, SM; Roobol, MJ; Jenster, G; van Schaik, RH; Hu, JJ; Sanderson, M; Kachuri, L; Varma, R; McKean-Cowdin, R; Torres, M; Preuss, MH; Loos, RJ; Zawistowski, M; Zöllner, S; Lu, Z; Van Den Eeden, SK; Easton, DF; Ambs, S; Edwards, TL; Mägi, R; Rebbeck, TR; Fritsche, L; Chanock, SJ; Berndt, SI; Wiklund, F; Nakagawa, H; Witte, JS; Gaziano, JM; Justice, AC; Mancuso, N; Terao, C; Eeles, RA; Kote-Jarai, Z; Madduri, RK; Conti, DV; Haiman, CA and
(2023)
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Nature genetics, 55 (12).
pp. 2065-2074.
ISSN 1061-4036
DOI: 10.1038/s41588-023-01534-4
; Shen, J; Rodriguez, AA; Saunders, EJ; Chen, F; Janivara, R; Darst, BF; Sheng, X; Xu, Y; Chou, AJ; +282 more...Benlloch, S; Dadaev, T; Brook, MN; Plym, A; Sahimi, A; Hoffman, TJ; Takahashi, A; Matsuda, K; Momozawa, Y; Fujita, M; Laisk, T; Figuerêdo, J; Muir, K; Ito, S; Liu, X; Biobank Japan Project; Uchio, Y; Kubo, M; Kamatani, Y; Lophatananon, A; Wan, P; Andrews, C; Lori, A; Choudhury, PP; Schleutker, J; Tammela, TL; Sipeky, C; Auvinen, A; Giles, GG; Southey, MC; MacInnis, RJ; Cybulski, C; Wokolorczyk, D; Lubinski, J; Rentsch, CT; Cho, K; Mcmahon, BH; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bojesen, SE; Røder, A; Stroomberg, HV; Batra, J; Chambers, S; Horvath, L; Clements, JA; Tilly, W; Risbridger, GP; Gronberg, H; Aly, M; Szulkin, R; Eklund, M; Nordstrom, T; Pashayan, N; Dunning, AM; Ghoussaini, M; Travis, RC; Key, TJ; Riboli, E; Park, JY; Sellers, TA; Lin, H; Albanes, D; Weinstein, S; Cook, MB; Mucci, LA; Giovannucci, E; Lindstrom, S; Kraft, P; Hunter, DJ; Penney, KL; Turman, C; Tangen, CM; Goodman, PJ; Thompson, IM; Hamilton, RJ; Fleshner, NE; Finelli, A; Parent, M; Stanford, JL; Ostrander, EA; Koutros, S; Beane Freeman, LE; Stampfer, M; Wolk, A; Håkansson, N; Andriole, GL; Hoover, RN; Machiela, MJ; Sørensen, KD; Borre, M; Blot, WJ; Zheng, W; Yeboah, ED; Mensah, JE; Lu, Y; Zhang, H; Feng, N; Mao, X; Wu, Y; Zhao, S; Sun, Z; Thibodeau, SN; McDonnell, SK; Schaid, DJ; West, CM; Barnett, G; Maier, C; Schnoeller, T; Luedeke, M; Kibel, AS; Drake, BF; Cussenot, O; Cancel-Tassin, G; Menegaux, F; Truong, T; Koudou, YA; John, EM; Grindedal, EM; Maehle, L; Khaw, K; Ingles, SA; Stern, MC; Vega, A; Gómez-Caamaño, A; Fachal, L; Rosenstein, BS; Kerns, SL; Ostrer, H; Teixeira, MR; Paulo, P; Brandão, A; Watya, S; Lubwama, A; Bensen, JT; Butler, EN; Mohler, JL; Taylor, JA; Kogevinas, M; Dierssen-Sotos, T; Castaño-Vinyals, G; Cannon-Albright, L; Teerlink, CC; Huff, CD; Pilie, P; Yu, Y; Bohlender, RJ; Gu, J; Strom, SS; Multigner, L; Blanchet, P; Brureau, L; Kaneva, R; Slavov, C; Mitev, V; Leach, RJ; Brenner, H; Chen, X; Holleczek, B; Schöttker, B; Klein, EA; Hsing, AW; Kittles, RA; Murphy, AB; Logothetis, CJ; Kim, J; Neuhausen, SL; Steele, L; Ding, YC; Isaacs, WB; Nemesure, B; Hennis, AJ; Carpten, J; Pandha, H; Michael, A; De Ruyck, K; De Meerleer, G; Ost, P; Xu, J; Razack, A; Lim, J; Teo, S; Newcomb, LF; Lin, DW; Fowke, JH; Neslund-Dudas, CM; Rybicki, BA; Gamulin, M; Lessel, D; Kulis, T; Usmani, N; Abraham, A; Singhal, S; Parliament, M; Claessens, F; Joniau, S; Van den Broeck, T; Gago-Dominguez, M; Castelao, JE; Martinez, ME; Larkin, S; Townsend, PA; Aukim-Hastie, C; Bush, WS; Aldrich, MC; Crawford, DC; Srivastava, S; Cullen, J; Petrovics, G; Casey, G; Wang, Y; Tettey, Y; Lachance, J; Tang, W; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Yamoah, K; Govindasami, K; Chokkalingam, AP; Keaton, JM; Hellwege, JN; Clark, PE; Jalloh, M; Gueye, SM; Niang, L; Ogunbiyi, O; Shittu, O; Amodu, O; Adebiyi, AO; Aisuodionoe-Shadrach, OI; Ajibola, HO; Jamda, MA; Oluwole, OP; Nwegbu, M; Adusei, B; Mante, S; Darkwa-Abrahams, A; Diop, H; Gundell, SM; Roobol, MJ; Jenster, G; van Schaik, RH; Hu, JJ; Sanderson, M; Kachuri, L; Varma, R; McKean-Cowdin, R; Torres, M; Preuss, MH; Loos, RJ; Zawistowski, M; Zöllner, S; Lu, Z; Van Den Eeden, SK; Easton, DF; Ambs, S; Edwards, TL; Mägi, R; Rebbeck, TR; Fritsche, L; Chanock, SJ; Berndt, SI; Wiklund, F; Nakagawa, H; Witte, JS; Gaziano, JM; Justice, AC; Mancuso, N; Terao, C; Eeles, RA; Kote-Jarai, Z; Madduri, RK; Conti, DV; Haiman, CA and
(2023)
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Nature genetics, 55 (12).
pp. 2065-2074.
ISSN 1061-4036
DOI: 10.1038/s41588-023-01534-4
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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subject - Accepted Version
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error - This is an author accepted manuscript version of an article accepted for publication, and following peer review. Please be aware that minor differences may exist between this version and the final version if you wish to cite from it.
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