Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.
Sanchez Clemente, Nuria;
Penner, Justin;
Breuer, Judith;
Ip, Winnie;
Booth, Claire;
(2022)
Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.
Frontiers in immunology, 13.
p. 881259.
ISSN 1664-3224
DOI: https://doi.org/10.3389/fimmu.2022.881259
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Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.