Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel.

Miner, Maurine D; Hatherill, Mark; Mave, Vidya; Gray, Glenda E; Nachman, Sharon; Read, Sarah W; White, Richard G; Hesseling, Anneke; Cobelens, Frank; Patel, Sheral; +22 more... Frick, Mike; Bailey, Theodore; Seder, Robert; Flynn, Joanne; Rengarajan, Jyothi; Kaushal, Deepak; Hanekom, Willem; Schmidt, Alexander C; Scriba, Thomas J; Nemes, Elisa; Andersen-Nissen, Erica; Landay, Alan; Dorman, Susan E; Aldrovandi, Grace; Cranmer, Lisa M; Day, Cheryl L; Garcia-Basteiro, Alberto L; Fiore-Gartland, Andrew; Mogg, Robin; Kublin, James G; Gupta, Amita; Churchyard, Gavin; (2022) Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel. The lancet. HIV, 9 (11). e791-e800. ISSN 2405-4704 DOI: https://doi.org/10.1016/S2352-3018(22)00255-7

Abstract

New tuberculosis vaccine candidates that are in the development pipeline need to be studied in people with HIV, who are at high risk of acquiring Mycobacterium tuberculosis infection and tuberculosis disease and tend to develop less robust vaccine-induced immune responses. To address the gaps in developing tuberculosis vaccines for people with HIV, a series of symposia was held that posed six framing questions to a panel of international experts: What is the use case or rationale for developing tuberculosis vaccines? What is the landscape of tuberculosis vaccines? Which vaccine candidates should be prioritised? What are the tuberculosis vaccine trial design considerations? What is the role of immunological correlates of protection? What are the gaps in preclinical models for studying tuberculosis vaccines? The international expert panel formulated consensus statements to each of the framing questions, with the intention of informing tuberculosis vaccine development and the prioritisation of clinical trials for inclusion of people with HIV.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & Dynamics (2023-)
Research Centre	Vaccine Centre TB Centre Centre for the Mathematical Modelling of Infectious Diseases TB Modelling Group
PubMed ID	36240834
Elements ID	195956
Official URL	http://dx.doi.org/10.1016/s2352-3018(22)00255-7

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