Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous.

Silva-Filho, JL; Lacerda, MV; Recker, M; Wassmer, SCORCID logo; Marti, M; Costa, FT and (2020) Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous. Trends in Parasitology, 36 (5). pp. 447-458. ISSN 1471-4922 DOI: 10.1016/j.pt.2020.03.002
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Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax.


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