Monte Carlo modelling of an x-ray chamber for providing inactivation exposures to viruses.
The Monte Carlo radiation transport code MCNP6 has been used to model dosimetry for biological pathogen samples placed within a MultiRad 225 irradiation chamber, in order to inform virus deactivation protocols. Full characterisations of the photon spectra generated by the chamber's x-ray tube were achieved for both 190 and 220 kV potentials, with and without aluminium and copper beam filters of different thicknesses. Dose rate maps to air and water within the chamber were then derived, along with corresponding conversion coefficient data. The maps were determined for samples located both on a shelf and on a dry ice refrigeration chamber, at different distances from the source. The potential depth-dose profiles through samples were also investigated. The optimum choice of filter for use in virus inactivation procedures will rely on a compromise between dose homogeneity and dose rate.
Item Type | Article |
---|---|
Elements ID | 195331 |
Official URL | http://dx.doi.org/10.1088/1361-6498/ac2f85 |
Date Deposited | 17 Jul 2023 10:53 |
-
picture_as_pdf - Eakins-etal-2021-Monte-carlo-modelling-of-an.pdf
-
subject - Accepted Version
-
error - This is an author accepted manuscript version of an article accepted for publication, and following peer review. Please be aware that minor differences may exist between this version and the final version if you wish to cite from it.
-
- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 4.0