Mensink-Bout, Sara M; van Meel, Evelien R; de Jongste, Johan C; Annesi-Maesano, Isabella; Aubert, Adrien M; Bernard, Jonathan Y; Chen, Ling-Wei; Cooper, Cyrus; Crozier, Sarah R; Hanke, Wojciech; +14 more... Harvey, Nicholas C; Hébert, James R; Heude, Barbara; Jerzynska, Joanna; Kelleher, Cecily C; Mehegan, John; McAuliffe, Fionnuala M; Phillips, Catherine M; Polanska, Kinga; Relton, Caroline L; Shivappa, Nitin; Suderman, Matthew; Jaddoe, Vincent WV; Duijts, Liesbeth; (2022) Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. The European respiratory journal, 59 (4). p. 2101315. ISSN 0903-1936 DOI: https://doi.org/10.1183/13993003.01315-2021
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Abstract
RATIONALE: Severe fetal malnutrition has been related to an increased risk of respiratory diseases later in life, but evidence for the association of a suboptimal diet during pregnancy with respiratory outcomes in childhood is conflicting. We aimed to examine whether a pro-inflammatory or low-quality maternal diet during pregnancy was associated with child's respiratory health. METHODS: We performed an individual participant meta-analysis among 18 326 mother-child pairs from seven European birth cohorts. Maternal pro-inflammatory and low-quality diets were estimated by energy-adjusted Dietary Inflammatory Index (E-DII) and Dietary Approaches to Stop Hypertension (DASH) scores. Preschool wheezing and school-age asthma were measured using questionnaires and lung function by spirometry. RESULTS: After adjustment for lifestyle and sociodemographic factors, we observed that a higher maternal E-DII score (a more pro-inflammatory diet) during pregnancy was associated only with a lower forced vital capacity (FVC) in children (z-score difference -0.05, 95% CI -0.08- -0.02, per interquartile range increase). No linear associations of the maternal E-DII or DASH score with child's wheezing or asthma were observed. In an exploratory examination of the extremes, a very low DASH score (<10th percentile) (a very low dietary quality) was associated with an increased risk of preschool wheezing and a low forced expiratory volume in 1 s/FVC (z-score <-1.64) (OR 1.20, 95% CI 1.06-1.36 and z-score difference 1.40, 95% CI 1.06-1.85, compared to ≥10th percentile), with corresponding population attributable risk fractions of 1.7% and 3.3%, respectively. CONCLUSION: The main results from this individual participant data meta-analysis do not support the hypothesis that maternal pro-inflammatory or low-quality diet in pregnancy are related to respiratory diseases in childhood.
Item Type | Article |
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Faculty and Department | Academic Services & Administration > Directorate |
PubMed ID | 34503987 |
Elements ID | 202024 |
Official URL | http://dx.doi.org/10.1183/13993003.01315-2021 |
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