Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Síle F
Molloy
;
Brad
Ross
;
Cecilia
Kanyama
;
Sayoki
Mfinanga
;
Sokoine
Lesikari
;
Robert S
Heyderman
;
Newton
Kalata
;
Jayne
Ellis
;
Charles
Kouanfack
;
Duncan
Chanda
;
+15 more...
Elvis
Temfack
;
Shabir
Lakhi
;
Anand
Moodley
;
Adrienne K
Chan
;
Joep J
van Oosterhout
;
Yacouba
Mapoure
;
Peter
Mwaba
;
David G
Lalloo
;
Duolao
Wang
;
Olivier
Lortholary
;
Shabbar
Jaffar
;
Mina C
Hosseinipour
;
Angela
Loyse
;
Thomas S
Harrison
;
Tihana
Bicanic
;
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open forum infectious diseases, 8 (4).
ofab066-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofab066
;
Newton
Kalata
;
Jayne
Ellis
;
Charles
Kouanfack
;
Duncan
Chanda
;
+15 more...
Elvis
Temfack
;
Shabir
Lakhi
;
Anand
Moodley
;
Adrienne K
Chan
;
Joep J
van Oosterhout
;
Yacouba
Mapoure
;
Peter
Mwaba
;
David G
Lalloo
;
Duolao
Wang
;
Olivier
Lortholary
;
Shabbar
Jaffar
;
Mina C
Hosseinipour
;
Angela
Loyse
;
Thomas S
Harrison
;
Tihana
Bicanic
;
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open forum infectious diseases, 8 (4).
ofab066-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofab066
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.
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picture_as_pdf - Molloy-etal-2021-Fungal-burden-and-raised-intracranial-pressure-are-independently-associated-with-visual-loss.pdf
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subject - Published Version
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- Available under Creative Commons: Attribution 4.0
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