Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Molloy, SF; Ross, B; Kanyama, C; Mfinanga, S; Lesikari, S; Heyderman, RS
; Kalata, N; Ellis, J; Kouanfack, C; Chanda, D; +15 more...Temfack, E; Lakhi, S; Moodley, A; Chan, AK; van Oosterhout, JJ; Mapoure, Y; Mwaba, P; Lalloo, DG; Wang, D; Lortholary, O; Jaffar, S; Hosseinipour, MC; Loyse, A; Harrison, TS; Bicanic, T and
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open forum infectious diseases, 8 (4).
ofab066-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofab066
; Kalata, N; Ellis, J; Kouanfack, C; Chanda, D; +15 more...Temfack, E; Lakhi, S; Moodley, A; Chan, AK; van Oosterhout, JJ; Mapoure, Y; Mwaba, P; Lalloo, DG; Wang, D; Lortholary, O; Jaffar, S; Hosseinipour, MC; Loyse, A; Harrison, TS; Bicanic, T and
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open forum infectious diseases, 8 (4).
ofab066-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofab066
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.
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