Comorbidity of alcohol use disorders and non-communicable diseases in low- and middle-income countries

Nadkarni, AORCID logo; Bhatia, UORCID logo; Shaik, I; Roy, M; Kaliyaperumal, A; Awasthi, A; Madan, V and (2023) Comorbidity of alcohol use disorders and non-communicable diseases in low- and middle-income countries. Journal of substance use, 29 (5). pp. 905-913. ISSN 1465-9891 DOI: 10.1080/14659891.2023.2202745
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Objective: The aim of this systematic review is to understand the relationship between alcohol use disorders (AUDs) and three non-communicable diseases [NCD] (cardiovascular diseases, respiratory diseases, and diabetes) in low- and middle-income countries (LMICs). Methods: We searched the following databases using a systematic search strategy: Medline, EMBASE, PsycINFO, Global Health, LILACS (Latin American and Caribbean Health Sciences Literature), and AJOL (African Journal Online). Results: We identified 1431 references through the database search and through a systematic screening process identified 13 studies that met our eligibility criteria. Amongst those with any kind of AUD, depending on the type of NCD, the prevalence ranged from 14% (diabetes) to 58% (hypertension). Amongst those with the selected NCDs, depending on the type of AUD, the prevalence ranged from 1.8% (diabetes) to 27.4% (ST-segment-elevation myocardial infarction). A range of AUDs were associated with hypertension in men, cardiovascular diseases, left ventricular hypertrophy, and diabetes mellitus. In some studies, inverse associations were observed between AUD and two NCDs–hypertension and diabetes. Conclusion: The burden of comorbid AUDs and NCDs in LMICs is high, and this should be countered through appropriate public health response such as policy interventions to control availability of alcohol, and through screening and brief interventions in primary care.


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This is an author accepted manuscript version of an article accepted for publication, and following peer review. Please be aware that minor differences may exist between this version and the final version if you wish to cite from it.
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