Effectiveness of BA.1- and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan.

Arashiro, TakeshiORCID logo; Arima, Yuzo; Kuramochi, Jin; Muraoka, Hirokazu; Sato, Akihiro; Chubachi, Kumi; Yanai, Atsushi; Arioka, Hiroko; Uehara, Yuki; Ihara, Genei; +22 more...Kato, Yasuyuki; Yanagisawa, Naoki; Ueda, Akihiro; Kato, HideakiORCID logo; Oka, Hideaki; Nishida, Yusuke; Nidaira, Yuki; Asami, TakahiroORCID logo; Jinta, Torahiko; Nakamura, Akira; Oba, Kunihiro; Taniyama, Daisuke; Yamamoto, Kei; Tanaka, Katsushi; Ueshima, Kankuro; Fuwa, Tetsuji; Stucky, Ashley; Suzuki, Tadaki; Smith, ChrisORCID logo; Hibberd, Martin; Ariyoshi, KoyaORCID logo; and Suzuki, Motoi (2023) Effectiveness of BA.1- and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan. Open forum infectious diseases, 10 (6). ofad240-. ISSN 2328-8957 DOI: 10.1093/ofid/ofad240
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In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared with no vaccination (65% and 76%) and moderate compared with monovalent vaccines administered over half a year earlier (46% combined).


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