Effectiveness of BA.1- and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan.

Takeshi Arashiro ORCID logo ; Yuzo Arima ; Jin Kuramochi ; Hirokazu Muraoka ; Akihiro Sato ; Kumi Chubachi ; Atsushi Yanai ; Hiroko Arioka ; Yuki Uehara ; Genei Ihara ; +22 more... Yasuyuki Kato ; Naoki Yanagisawa ; Akihiro Ueda ; Hideaki Kato ORCID logo ; Hideaki Oka ; Yusuke Nishida ; Yuki Nidaira ; Takahiro Asami ORCID logo ; Torahiko Jinta ; Akira Nakamura ; Kunihiro Oba ; Daisuke Taniyama ; Kei Yamamoto ; Katsushi Tanaka ; Kankuro Ueshima ; Tetsuji Fuwa ; Ashley Stucky ; Tadaki Suzuki ; Chris Smith ORCID logo ; Martin Hibberd ; Koya Ariyoshi ORCID logo ; Motoi Suzuki ; (2023) Effectiveness of BA.1- and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan. Open forum infectious diseases, 10 (6). ofad240-. ISSN 2328-8957 DOI: 10.1093/ofid/ofad240
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In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared with no vaccination (65% and 76%) and moderate compared with monovalent vaccines administered over half a year earlier (46% combined).


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