Miyano, Shinsuke; Vynnycky, Emilia; Pattamavone, Chansay; Ichimura, Yasunori; Mori, Yoshio; Nouanthong, Phonethipsavanh; Phounphenghack, Kongxay; Tengbriacheu, Chankham; Khamphaphongphane, Bouaphne; Franzel, Lauren; +7 more... Yang, Tae Un; Raaijimarkers, Hendrikus; Komada, Kenichi; Ota, Tomomi; Funato, Masafumi; Takeda, Makoto; Hachiya, Masahiko; (2023) Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program. International journal of infectious diseases, 129. pp. 70-77. ISSN 1201-9712 DOI: https://doi.org/10.1016/j.ijid.2023.01.044
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Abstract
OBJECTIVES: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys. METHODS: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019. RESULTS: We collected 2135 (women: 55.2%, mean age: 23.2 years) and 2001 (52.7%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9% (95% confidence interval [CI]: 83.8-84.0) to 98.3% (97.7-98.8) for measles and from 75.4% (75.3-75.5) to 87.8% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100% (95% CI: 28-100) since vaccination started, averting 78 (95% CI: 42-128) congenital rubella syndrome cases in 2019. CONCLUSION: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & Dynamics (2023-) |
PubMed ID | 36758852 |
Elements ID | 198692 |
Official URL | http://dx.doi.org/10.1016/j.ijid.2023.01.044 |
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