Healthcare challenges in low- and middle-income (LMICs) have been the focus of many digital initiatives that have aimed to ensure consistent implementation of these services. During the COVID-19 pandemic, several lockdowns were imposed globally by government authorities to contain the spread of the virus. This triggered a rapid effort to integrate digital technologies into the existing health systems of LMICs (1). Digital services have the potential to improve access and care coordination across health facilities by overcoming the conventional obstacles and weaknesses of traditional systems. To promote better adoption of digital health tools the challenges need to be understood and strategies to overcome barriers must be evaluated. Hence the aim of this Research Topic was to identify specific organizational and related barriers in implementing digital health in public health settings in LMICs and further explore facilitators for successful implementation of digital technologies.