Jullien, Sophie; Fitzgerald, Felicity; Keddie, Suzanne; Baerenbold, Oliver; Bassat, Quique; Bradley, John; Falconer, Jane; Fink, Colin; Keogh, Ruth; Hopkins, Heidi; +1 more... Voice, Marie; (2022) Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis. BMC infectious diseases, 22 (1). 785-. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-022-07766-9
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Abstract
Respiratory syncytial virus (RSV) and influenza viruses are important global causes of morbidity and mortality. We evaluated the diagnostic accuracy of the Luminex NxTAG respiratory pathogen panels (RPPs)™ (index) against other RPPs (comparator) for detection of RSV and influenza viruses. Studies comparing human clinical respiratory samples tested with the index and at least one comparator test were included. A random-effect latent class meta-analysis was performed to assess the specificity and sensitivity of the index test for RSV and influenza. Risk of bias was assessed using the QUADAS-2 tool and certainty of evidence using GRADE. Ten studies were included. For RSV, predicted sensitivity was 99% (95% credible interval [CrI] 96-100%) and specificity 100% (95% CrI 98-100%). For influenza A and B, predicted sensitivity was 97% (95% CrI 89-100) and 98% (95% CrI 88-100) respectively; specificity 100% (95% CrI 99-100) and 100% (95% CrI 99-100), respectively. Evidence was low certainty. Although index sensitivity and specificity were excellent, comparators' performance varied. Further research with clear patient recruitment strategies could ascertain performance across different populations.Protocol Registration: Prospero CRD42021272062.
Item Type | Article |
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Faculty and Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) ?? ADLA ?? Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
PubMed ID | 36229786 |
Elements ID | 195730 |
Official URL | http://dx.doi.org/10.1186/s12879-022-07766-9 |
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