Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries.

Nishath, TORCID logo; Li, X; Chandramohan, A; Othus, M; Ji, X; Zou, Y; Sultana, S; Rashid, R; Sherief, STORCID logo; Cassoux, N; +26 more...Garcia Leon, JL; Díaz Coronado, R; López, AMZ; Ushakova, TL; Polyakov, VG; Roy, SRORCID logo; Ahmad, A; Reddy, A; Sagoo, MS; Al Harby, LORCID logo; Kim, JW; Berry, JLORCID logo; Polski, A; Astbury, NORCID logo; Bascaran, CORCID logo; Blum, S; Bowman, RORCID logo; Burton, MJORCID logo; Foster, AORCID logo; Gomel, NORCID logo; Keren-Froim, N; Madgar, S; Zondervan, MORCID logo; Kaliki, SORCID logo; Fabian, IDORCID logo; Stacey, AORCID logo and (2022) Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries. The British journal of ophthalmology, 107 (12). pp. 1818-1822. ISSN 0007-1161 DOI: 10.1136/bjo-2022-321159
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BACKGROUND: Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients. METHODS: A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment. RESULTS: Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206). CONCLUSION: Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.


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This is an author accepted manuscript version of an article accepted for publication, and following peer review. Please be aware that minor differences may exist between this version and the final version if you wish to cite from it.
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