Vitamin D Deficiency and Its Association with Iron Deficiency in African Children.

Mogire, Reagan MORCID logo; Muriuki, John MuthiiORCID logo; Morovat, AlirezaORCID logo; Mentzer, Alexander J; Webb, Emily LORCID logo; Kimita, Wandia; Ndungu, Francis M; Macharia, Alex W; Cutland, Clare L; Sirima, Sodiomon B; +11 more...Diarra, Amidou; Tiono, Alfred BORCID logo; Lule, Swaib AORCID logo; Madhi, Shabir AORCID logo; Prentice, Andrew MORCID logo; Bejon, Philip; Pettifor, John MORCID logo; Elliott, Alison MORCID logo; Adeyemo, Adebowale; Williams, Thomas N; and Atkinson, Sarah HORCID logo (2022) Vitamin D Deficiency and Its Association with Iron Deficiency in African Children. NUTRIENTS, 14 (7). p. 1372. DOI: 10.3390/nu14071372
Copy

Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally, little is known about their interactions in Africa. To evaluate associations between vitamin D and iron status we measured markers of iron status, inflammation, malaria parasitemia, and 25-hydroxyvitamin D (25(OH)D) concentrations in 4509 children aged 0.3 months to 8 years living in Kenya, Uganda, Burkina Faso, The Gambia, and South Africa. Prevalence of iron deficiency was 35.1%, and prevalence of vitamin D deficiency was 0.6% and 7.8% as defined by 25(OH)D concentrations of <30 nmol/L and <50 nmol/L, respectively. Children with 25(OH)D concentrations of <50 nmol/L had a 98% increased risk of iron deficiency (OR 1.98 [95% CI 1.52, 2.58]) compared to those with 25(OH)D concentrations >75 nmol/L. 25(OH)D concentrations variably influenced individual markers of iron status. Inflammation interacted with 25(OH)D concentrations to predict ferritin levels. The link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies in African children.


picture_as_pdf
Mogire_etal_2022_Vitamin-D-Deficiency-and-Its Association.pdf
subject
Published Version
Available under Creative Commons: Attribution 4.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads