Parker, Edward PK; Bronowski, Christina; Sindhu, Kulandaipalayam Natarajan C; Babji, Sudhir; Benny, Blossom; Carmona-Vicente, Noelia; Chasweka, Nedson; Chinyama, End; Cunliffe, Nigel A; Dube, Queen; +19 more... Giri, Sidhartha; Grassly, Nicholas C; Gunasekaran, Annai; Howarth, Deborah; Immanuel, Sushil; Jere, Khuzwayo C; Kampmann, Beate; Lowe, Jenna; Mandolo, Jonathan; Praharaj, Ira; Rani, Bakthavatsalam Sandya; Silas, Sophia; Srinivasan, Vivek Kumar; Turner, Mark; Venugopal, Srinivasan; Verghese, Valsan Philip; Darby, Alistair C; Kang, Gagandeep; Iturriza-Gómara, Miren; (2021) Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants. Nature communications, 12 (1). 7288-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-021-27074-1
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Abstract
Identifying risk factors for impaired oral rotavirus vaccine (ORV) efficacy in low-income countries may lead to improvements in vaccine design and delivery. In this prospective cohort study, we measure maternal rotavirus antibodies, environmental enteric dysfunction (EED), and bacterial gut microbiota development among infants receiving two doses of Rotarix in India (n = 307), Malawi (n = 119), and the UK (n = 60), using standardised methods across cohorts. We observe ORV shedding and seroconversion rates to be significantly lower in Malawi and India than the UK. Maternal rotavirus-specific antibodies in serum and breastmilk are negatively correlated with ORV response in India and Malawi, mediated partly by a reduction in ORV shedding. In the UK, ORV shedding is not inhibited despite comparable maternal antibody levels to the other cohorts. In both India and Malawi, increased microbiota diversity is negatively correlated with ORV immunogenicity, suggesting that high early-life microbial exposure may contribute to impaired vaccine efficacy.
Item Type | Article |
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Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Research Centre | Vaccine Centre |
PubMed ID | 34911947 |
Elements ID | 168913 |
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Filename: Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian,.pdf
Licence: Creative Commons: Attribution 4.0
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