Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eyre, David W;
Sanderson, Nicholas D;
Lord, Emily;
Regisford-Reimmer, Natasha;
Chau, Kevin;
Barker, Leanne;
Morgan, Markus;
Newnham, Robert;
Golparian, Daniel;
Unemo, Magnus;
+7 more...Crook, Derrick W;
Peto, Tim Ea;
Hughes, Gwenda;
Cole, Michelle J;
Fifer, Helen;
Edwards, Anne;
Andersson, Monique I;
(2018)
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eurosurveillance, 23 (27).
pp. 2-7.
ISSN 1560-7917
DOI: https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323
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We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.