Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eyre, David W; Sanderson, Nicholas D; Lord, Emily; Regisford-Reimmer, Natasha; Chau, Kevin; Barker, Leanne; Morgan, Markus; Newnham, Robert; Golparian, Daniel; Unemo, Magnus; +7 more...Crook, Derrick W; Peto, Tim Ea; Hughes, Gwenda
; Cole, Michelle J; Fifer, Helen; Edwards, Anne; and Andersson, Monique I
(2018)
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eurosurveillance, 23 (27).
pp. 2-7.
ISSN 1560-7917
DOI: 10.2807/1560-7917.ES.2018.23.27.1800323
; Cole, Michelle J; Fifer, Helen; Edwards, Anne; and Andersson, Monique I
(2018)
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eurosurveillance, 23 (27).
pp. 2-7.
ISSN 1560-7917
DOI: 10.2807/1560-7917.ES.2018.23.27.1800323
We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.
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