Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study.
Stockdale, Lisa;
Sambou, Basil;
Sissoko, Muhamed;
Egere, Uzochukwu;
Sillah, Abdou K;
Kampmann, Beate;
Basu Roy, Robin;
(2021)
Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study.
European journal of pediatrics, 181 (3).
pp. 1263-1267.
ISSN 0340-6199
DOI: https://doi.org/10.1007/s00431-021-04272-z
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Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.