Lipid transport proteins in malaria, from Plasmodium parasites to their hosts.
Ressurreição, Margarida;
van Ooij, Christiaan;
(2021)
Lipid transport proteins in malaria, from Plasmodium parasites to their hosts.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (12).
159047-.
ISSN 1388-1981
DOI: https://doi.org/10.1016/j.bbalip.2021.159047
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Eukaryotic unicellular pathogens from the genus Plasmodium are the etiological agents of malaria, a disease that persists over a wide range of vertebrate species, including humans. During its dynamic lifecycle, survival in the different hosts depends on the parasite's ability to establish a suitable environmental milieu. To achieve this, specific host processes are exploited to support optimal growth, including extensive modifications to the infected host cell. These modifications include the formation of novel membranous structures, which are induced by the parasite. Consequently, to maintain a finely tuned and dynamic lipid environment, the organisation and distribution of lipids to different cell sites likely requires specialised lipid transfer proteins (LTPs). Indeed, several parasite and host-derived LTPs have been identified and shown to be essential at specific stages. Here we describe the roles of LTPs in parasite development and adaptation to its host including how the latest studies are profiting from the improved genetic, lipidomic and imaging toolkits available to study Plasmodium parasites. Lastly, a list of predicted Plasmodium LTPs is provided to encourage research in this field.