Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
Penetra, SL; da Silva, MF; Resende, P; Pina-Costa, A; Santos, HF; Guaraldo, L; Calvet, GA; Ogrzewalska, M; Arantes, I; Zukeram, K; +17 more...de Araújo, MF; Lima, ABM; Lopes, RS; Lira-Silva, LR; Moraes, IV; Wakimoto, MD; Fuller, TL; Gabaglia, CR; Espíndola, OM; Bonaldo, MC; Daniel-Ribeiro, CT; Whitworth, J
; Smith, C; Nielsen-Saines, K; Pauvolid-Correa, A; Siqueira, MM; Brasil, P and
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
; Smith, C; Nielsen-Saines, K; Pauvolid-Correa, A; Siqueira, MM; Brasil, P and
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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