Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
Penetra, Stephanie LS; da Silva, Michele FB; Resende, Paola; Pina-Costa, Anielle; Santos, Heloisa FP; Guaraldo, Lusiele; Calvet, Guilherme A; Ogrzewalska, Maria; Arantes, Ighor; Zukeram, Ketiuce; +17 more...de Araújo, Mia F; Lima, Ana Beatriz Machado; Lopes, Renata Serrano; Lira-Silva, Larissa R; Moraes, Isabella V; Wakimoto, Mayumi D; Fuller, Trevon L; Gabaglia, Claudia Raja; Espíndola, Otávio M; Bonaldo, Myrna C; Daniel-Ribeiro, Cláudio Tadeu; Whitworth, Jimmy
; Smith, Chris; Nielsen-Saines, Karin; Pauvolid-Correa, Alex; Siqueira, Marilda M; and Brasil, Patricia
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
; Smith, Chris; Nielsen-Saines, Karin; Pauvolid-Correa, Alex; Siqueira, Marilda M; and Brasil, Patricia
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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