Risk factors for asthma among schoolchildren who participated in a case-control study in urban Uganda.

Mpairwe, HORCID logo; Namutebi, M; Nkurunungi, GORCID logo; Tumwesige, P; Nambuya, I; Mukasa, M; Onen, C; Nnaluwooza, M; Apule, B; Katongole, T; +6 more...Oduru, G; Kahwa, J; Webb, ELORCID logo; Lubyayi, L; Pearce, NORCID logo; Elliott, AMORCID logo and (2019) Risk factors for asthma among schoolchildren who participated in a case-control study in urban Uganda. eLife, 8. ISSN 2050-084X DOI: 10.7554/eLife.49496
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Data on asthma aetiology in Africa are scarce. We investigated the risk factors for asthma among schoolchildren (5-17 years) in urban Uganda. We conducted a case-control study, among 555 cases and 1115 controls. Asthma was diagnosed by study clinicians. The main risk factors for asthma were tertiary education for fathers (adjusted OR (95% CI); 2.32 (1.71-3.16)) and mothers (1.85 (1.38-2.48)); area of residence at birth, with children born in a small town or in the city having an increased asthma risk compared to schoolchildren born in rural areas (2.16 (1.60-2.92)) and (2.79 (1.79-4.35)), respectively; father's and mother's history of asthma; children's own allergic conditions; atopy; and cooking on gas/electricity. In conclusion, asthma was associated with a strong rural-town-city risk gradient, higher parental socio-economic status and urbanicity. This work provides the basis for future studies to identify specific environmental/lifestyle factors responsible for increasing asthma risk among children in urban areas in LMICs.


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