Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania.
Nolan, Cody;
Reis, Karl;
Fadhil, Salama;
Etyang, Anthony;
Ezeomah, Chiomah;
Kingery, Justin R;
Desderius, Bernard;
Lee, Myung-Hee;
Kapiga, Saidi;
Peck, Robert N;
(2021)
Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania.
Journal of clinical hypertension (Greenwich, Conn.), 23 (7).
pp. 1452-1456.
ISSN 1524-6175
DOI: https://doi.org/10.1111/jch.14300
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People with HIV (PWH) have a >2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected controls with normal and high clinic blood pressure (BP) in Tanzania. Nocturnal non-dipping of heart rate (HR) was significantly more common among PWH than HIV-uninfected controls (p = .01). Nocturnal non-dipping of BP was significantly more common in PWH with normal clinic BP (p = .048). Clinical correlates of nocturnal non-dipping were similar in PWH and HIV-uninfected adults and included higher BMI, higher CD4+ cell count, and high C-reactive protein for HR and markers of renal disease for BP. In conclusion, nocturnal non-dipping of both BP and HR was more common in PWH but further research is needed to determine causes and consequences of this difference.
