LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis.

Siddiqi, Omar K; Ghebremichael, Musie; Musukuma, Kalo; Dang, Xin; Mubanga, Eugene; Birbeck, Gretchen L; Love, Shawn; Buback, Clayton; Kosloff, Barry; Ayles, Helen; +2 more... Atadzhanov, Masharip; Koralnik, Igor J; (2021) LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis. Annals of Neurology, 90 (6). pp. 994-998. ISSN 0364-5134 DOI: https://doi.org/10.1002/ana.26240

Abstract

We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994-998.