SARS-CoV-2 within-host diversity and transmission.

Lythgoe, KAORCID logo; Hall, MORCID logo; Ferretti, LORCID logo; de Cesare, MORCID logo; MacIntyre-Cockett, G; Trebes, AORCID logo; Andersson, MORCID logo; Otecko, N; Wise, ELORCID logo; Moore, NORCID logo; +28 more...Lynch, JORCID logo; Kidd, SORCID logo; Cortes, N; Mori, MORCID logo; Williams, RORCID logo; Vernet, GORCID logo; Justice, A; Green, AORCID logo; Nicholls, SMORCID logo; Ansari, MAORCID logo; Abeler-Dörner, LORCID logo; Moore, CEORCID logo; Peto, TEORCID logo; Eyre, DW; Shaw, RORCID logo; Simmonds, P; Buck, D; Todd, JAORCID logo; Oxford Virus Sequencing Analysis Group (OVSG); Connor, TRORCID logo; Ashraf, SORCID logo; da Silva Filipe, AORCID logo; Shepherd, JORCID logo; Thomson, ECORCID logo; COVID-19 Genomics UK (COG-UK) Consortium; Bonsall, DORCID logo; Fraser, CORCID logo; Golubchik, TORCID logo and COVID-19 Genomics UK (COG-UK) Consortium, Oxford Virus Sequencing Analysis Group (OVSG); (2021) SARS-CoV-2 within-host diversity and transmission. Science (New York, N.Y.), 372 (6539). 256-+. ISSN 0036-8075 DOI: 10.1126/science.abg0821
Copy

Extensive global sampling and sequencing of the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have enabled researchers to monitor its spread and to identify concerning new variants. Two important determinants of variant spread are how frequently they arise within individuals and how likely they are to be transmitted. To characterize within-host diversity and transmission, we deep-sequenced 1313 clinical samples from the United Kingdom. SARS-CoV-2 infections are characterized by low levels of within-host diversity when viral loads are high and by a narrow bottleneck at transmission. Most variants are either lost or occasionally fixed at the point of transmission, with minimal persistence of shared diversity, patterns that are readily observable on the phylogenetic tree. Our results suggest that transmission-enhancing and/or immune-escape SARS-CoV-2 variants are likely to arise infrequently but could spread rapidly if successfully transmitted.


picture_as_pdf
SARS-CoV-2 within-host diversity and transmission.pdf
subject
Published Version
Available under Creative Commons: Attribution 3.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads