Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya.

Ifedayo MO Adetifa ORCID logo ; Sophie Uyoga ORCID logo ; John N Gitonga ; Daisy Mugo ; Mark Otiende ORCID logo ; James Nyagwange ; Henry K Karanja ; James Tuju ; Perpetual Wanjiku ; Rashid Aman ; +25 more... Mercy Mwangangi ; Patrick Amoth ; Kadondi Kasera ; Wangari Ng'ang'a ; Charles Rombo ; Christine Yegon ; Khamisi Kithi ; Elizabeth Odhiambo ; Thomas Rotich ; Irene Orgut ; Sammy Kihara ; Christian Bottomley ORCID logo ; Eunice W Kagucia ORCID logo ; Katherine E Gallagher ORCID logo ; Anthony Etyang ; Shirine Voller ORCID logo ; Teresa Lambe ORCID logo ; Daniel Wright ORCID logo ; Edwine Barasa ; Benjamin Tsofa ; Philip Bejon ; Lynette I Ochola-Oyier ; Ambrose Agweyu ORCID logo ; J Anthony G Scott ORCID logo ; George M Warimwe ORCID logo ; (2021) Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya. Nature communications, 12 (1). 3966-. ISSN 2041-1723 DOI: 10.1038/s41467-021-24062-3
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Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.


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