Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya.

Etyang, AOORCID logo; Lucinde, R; Karanja, H; Kalu, C; Mugo, D; Nyagwange, J; Gitonga, J; Tuju, J; Wanjiku, P; Karani, A; +40 more...Mutua, S; Maroko, H; Nzomo, E; Maitha, E; Kamuri, E; Kaugiria, T; Weru, J; Ochola, LB; Kilimo, N; Charo, S; Emukule, N; Moracha, W; Mukabi, D; Okuku, R; Ogutu, M; Angujo, B; Otiende, MORCID logo; Bottomley, CORCID logo; Otieno, E; Ndwiga, L; Nyaguara, A; Voller, SORCID logo; Agoti, CN; Nokes, DJ; Ochola-Oyier, LI; Aman, R; Amoth, P; Mwangangi, M; Kasera, K; Ng'ang'a, W; Adetifa, IMORCID logo; Wangeci Kagucia, E; Gallagher, KORCID logo; Uyoga, S; Tsofa, B; Barasa, E; Bejon, P; Scott, JAGORCID logo; Agweyu, AORCID logo; Warimwe, GM and (2021) Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 74 (2). pp. 288-293. ISSN 1058-4838 DOI: 10.1093/cid/ciab346
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BACKGROUND: Few studies have assessed the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Africa. We report findings from a survey among HCWs in 3 counties in Kenya. METHODS: We recruited 684 HCWs from Kilifi (rural), Busia (rural), and Nairobi (urban) counties. The serosurvey was conducted between 30 July and 4 December 2020. We tested for immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay. Assay sensitivity and specificity were 92.7 (95% CI, 87.9-96.1) and 99.0% (95% CI, 98.1-99.5), respectively. We adjusted prevalence estimates, using bayesian modeling to account for assay performance. RESULTS: The crude overall seroprevalence was 19.7% (135 of 684). After adjustment for assay performance, seroprevalence was 20.8% (95% credible interval, 17.5%-24.4%). Seroprevalence varied significantly (P < .001) by site: 43.8% (95% credible interval, 35.8%-52.2%) in Nairobi, 12.6% (8.8%-17.1%) in Busia and 11.5% (7.2%-17.6%) in Kilifi. In a multivariable model controlling for age, sex, and site, professional cadre was not associated with differences in seroprevalence. CONCLUSION: These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.


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