N Costa, Maria Conceição; Cardim, Luciana Lobato; Teixeira, Maria Gloria; Barreto, Mauricio L; Carvalho-Sauer, Rita de Cassia Oliveira de; Barreto, Florisneide R; Carvalho, Martha Suely Itaparica; Oliveira, Wanderson K; França, Giovanny VA; Carmo, Eduardo Hage; +8 more... Andrade, Roberto FS; Rodrigues, Moreno S; Veiga, Rafael V; Oliveira, Juliane F; Fernandes, Qeren HRF; Costa, Larissa C; Coelho, Giovanini E; Paixao, Enny S; (2020) Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †. VIRUSES-BASEL, 12 (11). p. 1228. ISSN 1999-4915 DOI: https://doi.org/10.3390/v12111228
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Abstract
BACKGROUND: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child's health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child-maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015-2017. METHODS: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied. RESULTS: The microcephaly/CZS case fatality rate was 10% (95% CI 9.2-10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15; 95% CI 1.63-2.83), and very low birth weight (OR = 3.77; 95% CI 2.20-6.46); late preterm births (OR = 1.65; 95% CI 1.21-2.23), Apgar < 7 at 1st (OR = 5.98; 95% CI 4.46-8.02) and 5th minutes (OR = 4.13; 95% CI 2.78-6.13), among others. CONCLUSIONS: A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) |
Research Centre |
Maternal and Newborn Health Group Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 33138282 |
Elements ID | 154827 |
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Licence: Creative Commons: Attribution 3.0
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