Brasil, Patrícia; Vasconcelos, Zilton; Kerin, Tara; Gabaglia, Claudia Raja; Ribeiro, Ieda P; Bonaldo, Myrna C; Damasceno, Luana; Pone, Marcos V; Pone, Sheila; Zin, Andrea; +18 more... Tsui, Irena; Adachi, Kristina; Pereira, Jose Paulo; Gaw, Stephanie L; Carvalho, Liege; Cunha, Denise C; Guida, Leticia; Rocha, Mirza; Cherry, James D; Wang, Lulan; Aliyari, Saba; Cheng, Genhong; Foo, Suan-Sin; Chen, Weiqiang; Jung, Jae; Brickley, Elizabeth; Moreira, Maria Elisabeth L; Nielsen-Saines, Karin; (2020) Zika virus vertical transmission in children with confirmed antenatal exposure. NATURE COMMUNICATIONS, 11 (1). 3510-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-020-17331-0
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Abstract
We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015-2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) |
Research Centre |
Centre for Epidemic Preparedness and Response Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 32665616 |
Elements ID | 148981 |
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Filename: Zika virus vertical transmission in children with confirmed antenatal exposure.pdf
Licence: Creative Commons: Attribution 3.0
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