CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
; Maguire, Sarah; Morra, Anna; Kapoor, Pooja Middha; Tomczyk, Katarzyna; Jones, Michael E; Schoemaker, Minouk J; Gilham, Clare; Bolla, Manjeet K; Wang, Qin; +142 more...Dennis, Joe; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Baynes, Caroline; Freeman, Laura E Beane; Beckmann, Matthias W; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Boeckx, Bram; Bogdanova, Natalia V; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Campa, Daniele; Canzian, Federico; Castelao, Jose E; Chanock, Stephen J; Chenevix-Trench, Georgia; Clarke, Christine L; NBCS Collaborators; Conroy, Don M; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dörk, Thilo; Eliassen, A Heather; Engel, Christoph; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Floris, Giuseppe; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Closas, Montserrat; Gaudet, Mia M; Giles, Graham G; Goldberg, Mark S; González-Neira, Anna; AOCS Group; Guénel, Pascal; Hahnen, Eric; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann, Ute; Harrington, Patricia A; Hart, Steven N; Hooning, Maartje J; Hopper, John L; Howell, Anthony; Hunter, David J; ABCTB Investigators; kConFab Investigators; Jager, Agnes; Jakubowska, Anna; John, Esther M; Kaaks, Rudolf; Keeman, Renske; Khusnutdinova, Elza; Kitahara, Cari M; Kosma, Veli-Matti; Koutros, Stella; Kraft, Peter; Kristensen, Vessela N; Kurian, Allison W; Lambrechts, Diether; Le Marchand, Loic; Linet, Martha; Lubiński, Jan; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Martens, John WM; Mavroudis, Dimitrios; Mayes, Rebecca; Meindl, Alfons; Milne, Roger L; Neuhausen, Susan L; Nevanlinna, Heli; Newman, William G; Nielsen, Sune F; Nordestgaard, Børge G; Obi, Nadia; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orban, Ester; Park-Simon, Tjoung-Won; Peterlongo, Paolo; Plaseska-Karanfilska, Dijana; Pylkäs, Katri; Rennert, Gad; Rennert, Hedy S; Ruddy, Kathryn J; Saloustros, Emmanouil; Sandler, Dale P; Sawyer, Elinor J; Schmutzler, Rita K; Scott, Christopher; Shu, Xiao-Ou; Simard, Jacques; Smichkoska, Snezhana; Sohn, Christof; Southey, Melissa C; Spinelli, John J; Stone, Jennifer; Tamimi, Rulla M; Taylor, Jack A; Tollenaar, Rob AEM; Tomlinson, Ian; Troester, Melissa A; Truong, Thérèse; Vachon, Celine M; van Veen, Elke M; Wang, Sophia S; Weinberg, Clarice R; Wendt, Camilla; Wildiers, Hans; Winqvist, Robert; Wolk, Alicja; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison M; Pharoah, Paul DP; Easton, Douglas F; Howie, A Forbes; Peto, Julian; Dos-Santos-Silva, Isabel; Swerdlow, Anthony J; Chang-Claude, Jenny; Schmidt, Marjanka K; Orr, Nick; and Fletcher, Olivia
(2021)
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
British journal of cancer, 124 (4).
pp. 842-854.
ISSN 0007-0920
DOI: 10.1038/s41416-020-01185-w
BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. METHODS: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. RESULTS: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10-8). CONCLUSIONS: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
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