High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.

Seth C Inzaule ; Michael R Jordan ; George Bello ; Nellie Wadonda-Kabondo ; Salou Mounerou ; Innocent A Mbulli ; Sulaimon A Akanmu ; Adolfo Vubil ; Gillian Hunt ; Pontiano Kaleebu

; +8 more... Simangele Mthethwa-Hleza ; Janet Dzangare ; Patrick Njukeng ; Martina Penazzato ; Tobias F Rinke de Wit ; Susan H Eshleman ; Silvia Bertagnolio ; Infant HIV Drug Resistance Survey Team ; (2020) High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa. AIDS (London, England), 34 (10). pp. 1567-1570. ISSN 0269-9370 DOI: 10.1097/QAD.0000000000002580

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: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.