The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

Pereira, Marcos; Paixão, EnnyORCID logo; Trajman, Anete; de Souza, Ramon Andrade; da Natividade, Marcio Santos; Pescarini, Julia MORCID logo; Pereira, Susan Martins; Barreto, Florisneide Rodrigues; Ximenes, Ricardo; Dalcomo, Margareth; +4 more...Ichihara, Maria Yury; Nunes, Ceuci; Barral-Netto, Manoel; and Barreto, Maurício L (2020) The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19. RESPIRATORY RESEARCH, 21 (1). 178-. ISSN 1465-9921 DOI: 10.1186/s12931-020-01439-4
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Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.


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