Declaring a tuberculosis outbreak over with genomic epidemiology
Hollie-Ann
Hatherell
;
Xavier
Didelot
;
Sue L
Pollock
;
Patrick
Tang
;
Anamaria
Crisan
;
James C
Johnston
;
Caroline
Colijn
;
Jennifer L
Gardy
;
(2016)
Declaring a tuberculosis outbreak over with genomic epidemiology.
Microbial Genomics, 2 (5).
DOI: 10.1099/mgen.0.000060
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
Item Type | Article |
---|---|
Elements ID | 145140 |
Date Deposited | 05 Oct 2020 13:56 |