Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.
Tenforde, Mark W;
Milton, Thandi;
Rulaganyang, Ikanyeng;
Muthoga, Charles;
Tawe, Leabaneng;
Chiller, Tom;
Greene, Gregory;
Jordan, Alexander;
Williams, Christopher G;
Owen, Leah;
+5 more...Leeme, Tshepo B;
Boose, Amber;
Ngidi, Julia;
Mine, Madisa;
Jarvis, Joseph N;
(2020)
Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 72 (9).
pp. 1635-1638.
ISSN 1058-4838
DOI: https://doi.org/10.1093/cid/ciaa899
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Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.