Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.

Carlton, Jane M; Volkman, Sarah K; Uplekar, Swapna; Hupalo, Daniel N; Pereira Alves, João Marcelo; Cui, Liwang; Donnelly, Martin; Roos, David S; Harb, Omar S; Acosta, Monica; +7 more... Read, Andrew; Ribolla, Paulo EM; Singh, Om P; Valecha, Neena; Wassmer, Samuel C; Ferreira, Marcelo; Escalante, Ananias A; (2015) Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research. The American journal of tropical medicine and hygiene, 93 (3 Supp). pp. 87-98. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.15-0049

Abstract

The study of the three protagonists in malaria-the Plasmodium parasite, the Anopheles mosquito, and the human host-is key to developing methods to control and eventually eliminate the disease. Genomic technologies, including the recent development of next-generation sequencing, enable interrogation of this triangle to an unprecedented level of scrutiny, and promise exciting progress toward real-time epidemiology studies and the study of evolutionary adaptation. We discuss the use of genomics by the International Centers of Excellence for Malaria Research, a network of field sites and laboratories in malaria-endemic countries that undertake cutting-edge research, training, and technology transfer in malarious countries of the world.