White, Laura V; Edwards, Tansy; Lee, Nathaniel; Castro, Mary C; Saludar, Naomi R; Calapis, Rugaiya W; Faguer, Benjamin N; Fuente, Nelson Dela; Mayoga, Ferdinand; Saito, Nobuo; +4 more... Ariyoshi, Koya; Garfin, Anna Marie Celina G; Solon, Juan A; Cox, Sharon E; (2020) Patterns and predictors of co-morbidities in Tuberculosis: A cross-sectional study in the Philippines. Scientific reports, 10 (1). 4100-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-020-60942-2
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Abstract
Diabetes and undernutrition are common risk factors for TB, associated with poor treatment outcomes and exacerbated by TB. We aimed to assess non-communicable multimorbidity (co-occurrence of two or more medical conditions) in Filipino TB outpatients, focusing on malnutrition and diabetes. In a cross-sectional study, 637 adults (70% male) from clinics in urban Metro Manila (N = 338) and rural Negros Occidental (N = 299) were enrolled. Diabetes was defined as HbA1c of ≥6.5% and/or current diabetes medication. Study-specific HIV screening was conducted. The prevalence of diabetes was 9.2% (54/589, 95%CI: 7.0-11.8%) with 52% newly diagnosed. Moderate/severe undernutrition (body mass index (BMI) <17 kg/2) was 20.5% (130/634, 95%CI: 17.4-23.9%). Forty percent of participants had at least one co-morbidity (diabetes, moderate/severe undernutrition or moderate/severe anaemia (haemoglobin <11 g/dL)). HIV infection (24.4%, 74/303) was not associated with other co-morbidities (but high refusal in rural clinics). Central obesity assessed by waist-to-hip ratio was more strongly associated with diabetes (Adjusted Odds Ratio (AOR) = 6.16, 95%CI: 3.15-12.0) than BMI. Undernutrition was less common in men (AOR = 0.44, 95%CI: 0.28-0.70), and associated with previous history of TB (AOR = 1.97, 95%CI: 1.28-3.04) and recent reduced food intake. The prevalence of multimorbidity was high demonstrating a significant unmet need. HIV was not a risk factor for increased non-communicable multimorbidity.
Item Type | Article |
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Faculty and Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) |
Research Centre | TB Centre |
PubMed ID | 32139742 |
Elements ID | 145564 |
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