Pure tone audiometry and cerebral pathology in healthy older adults.

Parker, TORCID logo; Cash, DM; Lane, C; Lu, K; Malone, IB; Nicholas, JMORCID logo; James, S; Keshavan, A; Murray-Smith, H; Wong, A; +10 more...Buchannan, S; Keuss, S; Sudre, CH; Thomas, DORCID logo; Crutch, S; Bamiou, D; Warren, JD; Fox, NC; Richards, M; Schott, JM and (2019) Pure tone audiometry and cerebral pathology in healthy older adults. Journal of Neurology, Neurosurgery & Psychiatry, 91 (2). pp. 172-176. ISSN 0022-3050 DOI: 10.1136/jnnp-2019-321897
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BACKGROUND: Hearing impairment may be a modifiable risk factor for dementia. However, it is unclear how hearing associates with pathologies relevant to dementia in preclinical populations. METHODS: Data from 368 cognitively healthy individuals born during 1 week in 1946 (age range 69.2-71.9 years), who underwent structural MRI, 18F-florbetapir positron emission tomography, pure tone audiometry and cognitive testing as part of a neuroscience substudy the MRC National Survey of Health and Development were analysed. The aim of the analysis was to investigate whether pure tone audiometry performance predicted a range of cognitive and imaging outcomes relevant to dementia in older adults. RESULTS: There was some evidence that poorer pure tone audiometry performance was associated with lower primary auditory cortex thickness, but no evidence that it predicted in vivo β-amyloid deposition, white matter hyperintensity volume, hippocampal volume or Alzheimer's disease-pattern cortical thickness. A negative association between pure tone audiometry and mini-mental state examination score was observed, but this was no longer evident after excluding a test item assessing repetition of a single phrase. CONCLUSION: Pure tone audiometry performance did not predict concurrent β-amyloid deposition, small vessel disease or Alzheimer's disease-pattern neurodegeneration, and had limited impact on cognitive function, in healthy adults aged approximately 70 years.


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