GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
;
Shikta
Das
;
H Rob
Taal
;
Nicole M
Warrington
;
Alexandra M
Lewin
;
Marika
Kaakinen
;
Diana L
Cousminer
;
+83 more...
Elisabeth
Thiering
;
Nicholas J
Timpson
;
Tom A
Bond
;
Estelle
Lowry
;
Christopher D
Brown
;
Xavier
Estivill
;
Virpi
Lindi
;
Jonathan P
Bradfield
;
Frank
Geller
;
Doug
Speed
;
Lachlan JM
Coin
;
Marie
Loh
;
Sheila J
Barton
;
Lawrence J
Beilin
;
Hans
Bisgaard
;
Klaus
Bønnelykke
;
Rohia
Alili
;
Ida J
Hatoum
;
Katharina
Schramm
;
Rufus
Cartwright
;
Marie-Aline
Charles
;
Vincenzo
Salerno
;
Karine
Clément
;
Annique AJ
Claringbould
;
BIOS Consortium
;
Cornelia M
van Duijn
;
Elena
Moltchanova
;
Johan G
Eriksson
;
Cathy
Elks
;
Bjarke
Feenstra
;
Claudia
Flexeder
;
Stephen
Franks
;
Timothy M
Frayling
;
Rachel M
Freathy
;
Paul
Elliott
;
Elisabeth
Widén
;
Hakon
Hakonarson
;
Andrew T
Hattersley
;
Alina
Rodriguez
;
Marco
Banterle
;
Joachim
Heinrich
;
Barbara
Heude
;
John W
Holloway
;
Albert
Hofman
;
Elina
Hyppönen
;
Hazel
Inskip
;
Lee M
Kaplan
;
Asa K
Hedman
;
Esa
Läärä
;
Holger
Prokisch
;
Harald
Grallert
;
Timo A
Lakka
;
Debbie A
Lawlor
;
Mads
Melbye
;
Tarunveer S
Ahluwalia
;
Marcella
Marinelli
;
Iona Y
Millwood
;
Lyle J
Palmer
;
Craig E
Pennell
;
John R
Perry
;
Susan M
Ring
;
Markku J
Savolainen
;
Fernando
Rivadeneira
;
Marie
Standl
;
Jordi
Sunyer
;
Carla MT
Tiesler
;
Andre G
Uitterlinden
;
William
Schierding
;
Justin M
O'Sullivan
;
Inga
Prokopenko
;
Karl-Heinz
Herzig
;
George Davey
Smith
;
Paul
O'Reilly
;
Janine F
Felix
;
Jessica L
Buxton
;
Alexandra IF
Blakemore
;
Ken K
Ong
;
Vincent WV
Jaddoe
;
Struan FA
Grant
;
Sylvain
Sebert
;
Mark I
McCarthy
;
Marjo-Riitta
Järvelin
;
Early Growth Genetics (EGG) Consortium
;
(2019)
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
Science Advances, 5 (9).
eaaw3095-.
DOI: 10.1126/sciadv.aaw3095
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
-
picture_as_pdf - eaaw3095.full.pdf
-
subject - Published Version
-
- Available under Creative Commons: Attribution 3.0