Major subpopulations of Plasmodium falciparum in sub-Saharan Africa.

Amambua-Ngwa, AORCID logo; Amenga-Etego, LORCID logo; Kamau, EORCID logo; Amato, RORCID logo; Ghansah, A; Golassa, LORCID logo; Randrianarivelojosia, MORCID logo; Ishengoma, D; Apinjoh, T; Maïga-Ascofaré, OORCID logo; +11 more...Andagalu, B; Yavo, WORCID logo; Bouyou-Akotet, MORCID logo; Kolapo, O; Mane, KORCID logo; Worwui, AORCID logo; Jeffries, DORCID logo; Simpson, VORCID logo; D'Alessandro, UORCID logo; Kwiatkowski, DORCID logo; Djimde, AAORCID logo and (2019) Major subpopulations of Plasmodium falciparum in sub-Saharan Africa. SCIENCE, 365 (6455). pp. 813-816. ISSN 0036-8075 DOI: 10.1126/science.aav5427
Copy

Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against P. falciparum malaria.


picture_as_pdf
Major-subpopulations-of-Plasmodium-falciparum-in-sub-Saharan-Africa.pdf
subject
Accepted Version
Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads